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KMID : 0378019800230070049
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New Medical Journal
1980 Volume.23 No. 7 p.49 ~ p.60
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Isoantigens A, B and H in Benign and Malignant Lesions of the Breast
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Abstract
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Two hundred and thirty eight cases of breast lesions were studied by the technique of mixed cell agglutination reaction (MCAR) to investigate the distribution and preser vation of isoantigens A, B and H(0) in various breast diseases.
MCAR was strongly positive at the epithelium in all of the 58 cases with fibroadenoma and 5 cases with gynecomastia. On the other hand, in breast carcinoma, the majority showed negative reaction and the loss of the antigens was increasingly progressive from intraductal carcinoma to anaplastic, invasive and metastatic carcinoma. Mammary iysplasia and the remaining breast adjacent to the carcinoma were devoid of isoantigens in a few cases, and the severer the degree of large duct epithelial hyperplasia, the more frequent the loss of isoantigens was noted.
In veiw of these findings, it seemed that the isoantigens in breast carcinomas are almost always lost, while in the benign lesions isoantigens are nearly always present. A few cases of noncancerous breast tissue near the carcinoma and mammary dysplasia showed complete loss or weak reaction for MCAR, and this might be a helpful feature for presumtive diagnosis for possible malignancy when diagnostic biopsy was failed to obtain the cancer tissue proper.
The generally accepted criteria of malignancy are anaplasia, the morphologic dedifferentiation. We interpreted the loss of A, B and H isoantigens as the result of immunologic dedifferentiation in the course of cancerous transformation, which is analogous to morphologic dedifferentiation. Furthermore it seemed that the functional dedifferentiation preceded the morphologic anaplasia, as other reports suggested.
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